Loading...
Please wait, while we are loading the content...
Similar Documents
Significant Regulatory Networks from Goto-Kakizaki Rat Liver Microarray Data during Diabetic Progression
| Content Provider | Semantic Scholar |
|---|---|
| Author | Zhou, Huarong Saito, Shigeru Piao, Guanying Hu, Rongkuan Wang, Jiguang Liu, Zhi-Ping Horimoto, Katsuhisa |
| Copyright Year | 2010 |
| Abstract | In the aim of identifying significant transcriptional regulatory networks in the liver contributing to diabetes, we have performed comprehensive active regulatory network survey by network screening in 4weeks (w), 8-12w, and 18-20w Goto-Kakizaki (GK) rat liver microarray data. The comprehensive survey of the consistency between the networks and the measured data by the network screening approach in the case of non-insulin dependent diabetes in the GK rat reveals: 1. More pathways are active during inter-middle stage diabetes; 2. Inflammation, hypoxia, increased apoptosis, decreased proliferation, and altered metabolism are characteristics and display as early as 4weeks in GK strain; 3. Diabetes progression accompanies insults and compensations; |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.aporc.org/LNOR/13/ISB2010F27.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
