NDLI: Kinetic and Mechanistic Investigation on Oxidation of Levamisole hydrochloride by Bromamine-T in Hydrochloric acid Medium

Please wait, while we are loading the content...

Kinetic and Mechanistic Investigation on Oxidation of Levamisole hydrochloride by Bromamine-T in Hydrochloric acid Medium

Content Provider	Semantic Scholar
Author	Rangaraju, Pr Venkatesha, T. V. Ramachandrappa, Raghavendra Kanchipura
Copyright Year	2014
Abstract	Kinetics of oxidation of Levamisole hydrochloride (LVM) by sodium N-bromo-p-toluene sulfonamide or bromamine-T (BAT) in presence of HCl has been investigated at 303K. The Stoichiometry of the reaction was found to be 1:1 and the oxidation product of levamisole hydrochloride was identified as Levamisole S-oxide was characterized by GC-MS analysis. The rate of reaction shows first-order dependence on (BAT)0, (LVM)0 and fractional-order dependence with (H + )0. Effects of added p- toluene sulfonamide (PTS) and halide ions, varying ionic strength (NaClO4) and dielectric constant of the medium on the rate of reaction have been investigated. Activation parameters were calculated and the reaction constants involved in the mechanisms have been computed. The proposed mechanisms and the derived rate laws are consistent with the observed kinetics. Keywords: Kinetics, Levamisole hydrochloride, oxidation, bromamine-T, mechanism.
Starting Page	30
Ending Page	37
Page Count	8
File Format	PDF HTM / HTML
DOI	10.6084/m9.figshare.1128500
Volume Number	7
Alternate Webpage(s)	http://www.iosrjournals.org/iosr-jac/papers/vol7-issue7/Version-2/F07723037.pdf
Alternate Webpage(s)	https://doi.org/10.6084/m9.figshare.1128500
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in