NDLI: Low-dose pretreatment with clorgyline decreases the levels of 3-methoxy-4-hydroxyphenylglycol in the striatum and nucleus accumbens and attenuates methamphetamine-induced conditioned place preference in rats

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Low-dose pretreatment with clorgyline decreases the levels of 3-methoxy-4-hydroxyphenylglycol in the striatum and nucleus accumbens and attenuates methamphetamine-induced conditioned place preference in rats

Content Provider	Semantic Scholar
Author	Kitanaka, Nobue Kitanaka, Junichi Watabe, Kazushige Takemura, Motohiko
Copyright Year	2010
Abstract	The effect of treating rats with clorgyline, an irreversible monoamine oxidase-A (MAO-A) inhibitor, on methamphetamine (METH)-induced conditioned place preference (CPP) was investigated. Administering rats with METH (1.0 mg/kg i.p.) every other day during two conditioning sessions (i.e., saline/METH conditioning with no clorgyline pretreatment) induced a significant CPP compared with saline/saline conditioning. Pretreatment of the rats with clorgyline at a dose of 0.1 mg/kg (i.p.), but not 1.0 or 10 mg/kg, attenuated the METH-induced CPP. Neurochemical analysis using high-performance liquid chromatography revealed that the tissue levels of monoamines and their metabolites were not significantly affected by treatment with 0.1 mg/kg clorgyline except for the levels of 3-methoxy4-hydroxyphenylglycol (MHPG) in the striatum and nucleus accumbens (NAc). Clorgyline at doses of 1.0 or 10 mg/kg significantly affected the tissue levels of 3,4-dihydroxyphenylacetic acid, norepinephrine (NE), MHPG, and serotonin in the cerebral cortex and those of all monoamines and metabolites examined in the striatum and NAc. A significant decrease in the MHPG/NE ratio in the striatum and NAc was apparent in the rats pretreated with 0.1 mg/kg clorgyline. Overall, the present study demonstrated that low-dose clorgyline attenuated METH-induced CPP in rats.
Starting Page	1370
Ending Page	1376
Page Count	7
File Format	PDF HTM / HTML
DOI	10.1016/j.neuroscience.2009.11.058
PubMed reference number	19958817
Journal	Medline
Volume Number	165
Alternate Webpage(s)	https://api.elsevier.com/content/article/pii/S0306452209019691
Alternate Webpage(s)	https://www.sciencedirect.com/science/article/pii/S0306452209019691?dgcid=api_sd_search-api-endpoint
Journal	Neuroscience
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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