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Neonatal tetanus despite protective serum antitoxin concentration.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Maselle, Samwel Y. Matre, Roald Mbise, Roger L. Hofstad, Tor |
| Copyright Year | 1991 |
| Abstract | Using the ELISA technique to estimate serum antibodies against tetanus toxin, seven neonates with clinical tetanus were found to have antibody levels 4-13 times higher than the presumed minimum protective level of 0.01 IU/ml. All but one of their mothers had been vaccinated with tetanus toxoid in pregnancy. In two other neonates, whose mothers had received multiple booster doses of toxoid during pregnancy, the anti-toxin concentrations were 100- and 400-times the presumed protective level. Therefore the toxin dose may overwhelm the pre-existing anti-toxin level and produce disease. Furthermore, multiple booster injections of tetanus toxoid may not only enhance serum anti-toxin titres, but could also lead to an ineffective immune response. |
| Starting Page | 306 |
| Ending Page | 312 |
| Page Count | 7 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://oup.silverchair-cdn.com/oup/backfile/Content_public/Journal/femspd/3/3/10.1111_j.1574-6968.1991.tb04211.x/2/3-3-171.pdf?Expires=1492977986&Key-Pair-Id=APKAIUCZBIA4LVPAVW3Q&Signature=KWWOHaugBvWJQWgqWqnQbL4eEx-cZabcTU~tzjiwVzMK9PFFgUwVQWoHtttANRURmujVxOPCvfypKsy9C67J4E9vqtqIaExti50S4WdVsoFa07yQ8hceN07PxVK6Dq0A3-Jh7709bBzUv~L95Te1khAb2uq5F6mgoE7xJDQInYxu8NXxaVYrvAJ7ZBl6mKDYLmDj4sTx5XA6WCf2d~P9NyMpC7P6hGhYVmP9ahMmejAsBwOJ2ypIuVpxEKMLuJ46U~eX~zuPKftlVT3cyROCc-jFD~tYagZ5fycpfDTJa03HyCyEBLjnylWGk8FB5dPRkP2LUfbMaNgTDvsVQ15OgQ__ |
| PubMed reference number | 1878260v1 |
| Volume Number | 3 |
| Issue Number | 3 |
| Journal | FEMS microbiology immunology |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Antitoxins Booster Immunization - ActSubstanceAdministrationCode Enzyme-Linked Immunosorbent Assay Infant, Newborn Tetanus Neonatorum Toxoids tetanus toxin tetanus toxoid vaccine, inactivated |
| Content Type | Text |
| Resource Type | Article |