NDLI: Nitrocompostos e extratos orgânicos de partículas aéreas são indutores de toxicidade genética em células somáticas de Drosophila melanogaster

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Nitrocompostos e extratos orgânicos de partículas aéreas são indutores de toxicidade genética em células somáticas de Drosophila melanogaster

Content Provider	Semantic Scholar
Author	Dihl, Rafael R.
Copyright Year	2008
Abstract	Considering the several adverse effects of atmospheric particulate matter (PM) and of the environment chemical contaminants on the ecosystems and human health, the present study aimed to assess the mutagenic and recombinagenic potential of PM10 organic extracts measuring less than 10 μm and of total suspended particulates (TSP) collected in the Greater Canoas region, in November 2003 (spring) and January 2004 (summer). The region is under the influence of diverse industrial activities and most specially of intense motor vehicle traffic from BR116. This study also investigated four nitropolycyclic aromatic hydrocarbons (NPAHs) of environmental relevance: 1Nitronaphthalene (1NN); 1,5-Dinitronaphthalene (1,5DNN); 9-Nitroanthracene (9NA); and 2-Nitrofluorene (2NF). The Somatic Mutation and Recombination Test (SMART) in Drosophila melanogaster was used. The assay allows the simultaneous detection of gene and chromosome mutations, as well as of events related to mitotic recombination, which affords to quantify the contribution of this last genetic parameter to total genotoxicity of contaminants. As regards PM, no positive results were observed in the standard cross for the summer collection, although the spring samples generated two positive results for the raw (100%) PM10 and TSP samples. Nevertheless, while the genotoxins present in PM10 induced only homologous recombination, the TSP samples presented roughly 62% of recombinational activity and 38% of gene and/or chromosome mutation activity. This distinct genotoxic response may be related to the different composition of contaminants present in these two
File Format	PDF HTM / HTML
Alternate Webpage(s)	https://www.lume.ufrgs.br/bitstream/handle/10183/13613/000638532.pdf?isAllowed=y&sequence=1
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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