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Effects of nitrous oxide (N2O) on spinal cord potentials (SCPs) and cerebral evoked potentials (CEPs) elicited by electrical shocks
| Content Provider | Semantic Scholar |
|---|---|
| Author | Shimoji, Koki Maruyama, Yoichi Fujioka, H. Sato, Yasushi Shimizu, Hirotoshi |
| Copyright Year | 1984 |
| Abstract | POTENTIALS (SCPs) AND CEREBiAL (CEPs) ELICITED BY ELECTRICAL SHOCKS Y. Maruyama*, H. Fujioka*, Y. Sate* Department of Anesthesiology, Niigata University School of Medicine, Niigata 951, Japan Aim of Investigation: Electrical shocks applied to front and hind paws produced segmental (S-) and intersegmental (IS-) SCPs in rats. The amplitudes and wave-forms of SCPS and CEPs are related to both level and site of stimulations. This study tested the effects of weak versus strong shocks applied to paws on the SCPs and CEPs before and during N 0 inhalation. Methods: The dorsal surface of the spinal co d was exposed 4 by means of laminectomies at C6 and L levels to record the SCPs in rats anesthetized with pentobibital (50 mg/kg, i.p.). Exposure of the cord was made also at Ll level for spinal transection. The CEPs were recorded from the area of the anterior sigmoid. N20 (25, 50, 75%) was inhaled through an intratracheal cannula. Results: A significant reduction in amplitude of S-SCP, IS-SCP and CEP components was observed by N20 administration. The amplitude reduction was larger with strong shocks than with weak shocks. The suppressive effects of N 0 on these components of SCPs and CEPs were not antagonize g by naloxone (0.1-5 mg/kg) in both intact and spinal animals. Conclusions: N 0 affected both spinal and supraspinal structures. The s ppressive effect of N 0 was more directed 2 to the responses evoked by strong stimul 1 than to those by weak stimuli, and might be produced through a non-opioid system. |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/0304-3959(84)90747-4 |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/0304395984907474 |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/0304395984907474?dgcid=api_sd_search-api-endpoint |
| Alternate Webpage(s) | https://doi.org/10.1016/0304-3959%2884%2990747-4 |
| Volume Number | 18 |
| Journal | PAIN |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
