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Supramolecular assemblies based on amphiphilic Mn2+-complexes as high relaxivity MRI probes.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Rolla, Gabriele A. Biasio, Valeria De Giovenzana, Giovanni B. Botta, Mauro Tei, Lorenzo |
| Copyright Year | 2018 |
| Abstract | In the research field of MRI contrast agents (CAs), amphiphilic paramagnetic complexes are typically sought for the increased plasmatic half-life and high relaxivity values, but limited examples of amphiphilic Mn2+-based CAs have been reported to date. In this work the Mn2+-complexes of six original amphiphilic ligands (three EDTA-like ligands and three 1,4-DO2A derivatives) embodying one or two aliphatic chains were evaluated as potential MRI contrast agents and compared. Strong self-association into micelles resulted in a relaxivity (r1) enhancement (ca. 80% with respect to MnEDTA) as a consequence of the increased molecular tumbling rate of the supramolecular aggregate. In the case of bis-substituted systems the r1 gain is much higher due to the restricted local rotation of the chelates about the pendant aliphatic chains (r1 in the range 12.6-18.4 mM-1 s-1, 2-3 times higher than for the micelles obtained with single-chain EDTA systems). Furthermore, these amphiphilic chelates tightly bind to human serum albumin (HSA) with association constants KA in the range 104-105 M-1. The resulting supramolecular adducts achieve remarkable relaxivity values, in the range 50-60 mM-1 s-1 for the MnEDTA-like chelates and 27-30 mM-1 s-1 for the 1,4-DO2A-like systems (at 298 K and 20 MHz), thanks to their fast water exchange rate. |
| Starting Page | 10660 |
| Ending Page | 10670 |
| Page Count | 11 |
| File Format | PDF HTM / HTML |
| DOI | 10.1039/c8dt01250d |
| PubMed reference number | 29868661 |
| Journal | Medline |
| Volume Number | 47 |
| Issue Number | 31 |
| Alternate Webpage(s) | http://www.rsc.org/suppdata/c8/dt/c8dt01250d/c8dt01250d1.pdf |
| Alternate Webpage(s) | https://doi.org/10.1039/c8dt01250d |
| Journal | Dalton transactions |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
