Genotoxic Potential of Senecio trapezuntinus in Cultured Human Lymphocytes

Content Provider	Semantic Scholar
Author	Eroğlu, Halil Erhan Hamzaoğlu, Ergin Aksoy, Ahmet Budak, Ümit Albayrak, Sevil
Copyright Year	2009
Abstract	Abstract The in vitro genotoxic potential of methanol extract of Senecio trapezuntinus in human lymphocytes was investigated. Blood samples were obtained from six healthy donors, non-smoking volunteers, who were incubated and exposed to increasing concentrations of Senecio trapezuntinus (0.002, 0.01, 0.05 and 0.1 mg/mL). Senecio trapezuntinus induced micronucleus, decreased mitotic and proliferation indexes in human lymphocytes (P<0.01 for 0.05 and 0.1 mg/mL). While the decreases of mitotic and proliferation indexes indicate that Senecio trapezuntinus is an antiproliferative and antimitotic agent, the rise of micronucleus shows that Senecio trapezuntinus at high concentrations may become carcinogenic and genotoxic.
Starting Page	303
Ending Page	308
Page Count	6
File Format	PDF HTM / HTML
Volume Number	62
Alternate Webpage(s)	http://www.caryologia.unifi.it/past_volumes/62_4/05-1551.pdf
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article