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No association between blood telomere length and longitudinally assessed diet or adiposity in a young adult Filipino population
| Content Provider | Semantic Scholar |
|---|---|
| Author | Bethancourt, Hilary J. Kratz, Mario Beresford, Shirley A. A. Hayes, M. Geoffrey Kuzawa, Christopher W. Duazo, Paulita Borja, Judith B. Eisenberg, Daniel |
| Copyright Year | 2015 |
| Abstract | PurposeTelomeres, DNA–protein structures that cap and protect chromosomes, are thought to shorten more rapidly when exposed to chronic inflammation and oxidative stress. Diet and nutritional status may be a source of inflammation and oxidative stress. However, relationships between telomere length (TL) and diet or adiposity have primarily been studied cross-sectionally among older, overweight/obese populations and yielded inconsistent results. Little is known about the relationship between diet or body composition and TL among younger, low- to normal-weight populations. It also remains unclear how cumulative exposure to a specific diet or body composition during the years of growth and development, when telomere attrition is most rapid, may be related to TL in adulthood.MethodsIn a sample of 1459 young adult Filipinos, we assessed the relationship between blood TL at ages 20.8–22.5 and measures of BMI z-score, waist circumference, and diet collected between the ages of 8.5 and 22.5. TL was measured using monochrome multiplex quantitative PCR, and diet was measured using multiple 24-h recalls.ResultsWe found no associations between blood TL and any of the measures of adiposity or between blood TL and the seven dietary factors examined: processed meats, fried/grilled meats and fish, non-fried fish, coconut oil, fruits and vegetables, bread and bread products, and sugar-sweetened beverages.ConclusionsConsidering the inconsistencies in the literature and our null results, small differences in body composition and consumption of any single pro- or anti-inflammatory dietary component may not by themselves have a meaningful impact on telomere integrity, or the impact may differ across distinct ecological circumstances. |
| Starting Page | 295 |
| Ending Page | 308 |
| Page Count | 14 |
| File Format | PDF HTM / HTML |
| DOI | 10.1007/s00394-015-1080-1 |
| Alternate Webpage(s) | http://faculty.washington.edu/dtae/manuscripts/bethancourt%20-%20No%20association%20between%20blood%20telomere%20length%20and%20longitudinally.pdf |
| PubMed reference number | 26497538 |
| Alternate Webpage(s) | https://doi.org/10.1007/s00394-015-1080-1 |
| Journal | Medline |
| Volume Number | 56 |
| Journal | European Journal of Nutrition |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
