NDLI: Extracorporeal Photopheresis of Cutaneous T-Cell Lymphoma Is Associated with Reduction of Peripheral CD4+ T Lymphocytes

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Extracorporeal Photopheresis of Cutaneous T-Cell Lymphoma Is Associated with Reduction of Peripheral CD4+ T Lymphocytes

Content Provider	Semantic Scholar
Author	Zouboulis, Christos C. Schmuth, Matthias Döpfmer, Susanne Dippel, Edgar Orfanos, Constantin E.
Copyright Year	1998
Abstract	Background: Extracorporeal photopheresis (ECP) has been successfully introduced for the treatment of cutaneous T-cell lymphoma; however, the mechanism(s) of its action is (are) unknown. Objective: To investigate the effects of ECP on the immune system of patients with cutaneous T-cell lymphoma. Methods: Clinical response and changes of lymphocyte subpopulations in 20 patients with cutaneous T-cell lymphoma under ECP monotherapy or combined regimens were evaluated and compared after 3, 6 and 12 ECP cycles. Results: Thirteen of 20 patients showed a ≥50% reduction of skin lesions after 6–12 ECP cycles. An overall T-lymphocyte reduction was assessed with a balanced CD4+ T-helper and CD8+ T-suppressor cell decrease in responders. In contrast, there was a trend of CD4+ T-helper cell increase in nonresponders which could result from the failure of treatment to control the natural course of the disease. The CD4+/CD8+ ratios were 1.6 at baseline and 1.4 after 12 cycles in responders, while they increased from 1.7 to 4.1 in nonresponders, respectively (p = 0.047). In addition, there was an overall decrease in the CD57+/CD8+ T-cell subpopulation mostly due to a reduction in the responder group. Conclusion: The marked differences detected in certain T-cell subpopulations suggest an effect of ECP on peripheral T lymphocytes and, especially, on CD4+ cells.
Starting Page	305
Ending Page	308
Page Count	4
File Format	PDF HTM / HTML
DOI	10.1159/000017926
Alternate Webpage(s)	http://www.klinikum-dessau.de/fileadmin/user_upload/Hautklinik/PDF-Files/71_ecp.pdf
PubMed reference number	9621137
Alternate Webpage(s)	https://doi.org/10.1159/000017926
Journal	Medline
Volume Number	196
Journal	Dermatology
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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