Mechanisms of atherothrombosis in chronic obstructive pulmonary disease

Content Provider	Semantic Scholar
Author	Fimognari, Filippo Luca Scarlata, Simone Conte, Maria Elisabetta Incalzi, Raffaele Antonelli
Copyright Year	2008
Abstract	Patients affected by chronic obstructive pulmonary disease (COPD) have an increased risk of atherothrombotic acute events, independent of smoking and other cardiovascular risk factors. As a consequence, myocardial ischemia is a relevant cause of death in these patients. We reviewed studies concerning the potential mechanisms of atherothrombosis in COPD. Bronchial inflammation spreads to the systemic circulation and is known to play a key role in plaque formation and rupture. In fact, C-reactive protein blood levels increase in COPD and provide independent prognostic information. Systemic inflammation is the first cause of the hypercoagulable state commonly observed in COPD. Furthermore, hypoxia is supposed to activate platelets, thus accounting for the increased urinary excretion of platelet-derived thromboxane in COPD. The potential metabolic risk in COPD is still debated, in that recent studies do not support an association between COPD and diabetes mellitus. Finally, oxidative stress contributes to the pathogenesis of COPD and may promote oxidation of low-density-lipoproteins with foam cells formation. Retrospective observations suggest that inhaled corticosteroids may reduce atherothrombotic mortality by attenuating systemic inflammation, but this benefit needs confirmation in ongoing randomized controlled trials. Physicians approaching COPD patients should always be aware of the systemic vascular implications of this disease.
Starting Page	89
Ending Page	96
Page Count	8
File Format	PDF HTM / HTML
PubMed reference number	18488431
Volume Number	3
Journal	International journal of chronic obstructive pulmonary disease
Alternate Webpage(s)	https://www.dovepress.com/getfile.php?fileID=2325
Alternate Webpage(s)	http://ftp.ncbi.nlm.nih.gov/pub/pmc/fc/dd/copd-0301-89.PMC2528208.pdf
Language	English
Access Restriction	Open
Subject Keyword	Activation action Blood Platelets C-reactive protein Cessation of life Chronic Obstructive Airway Disease Dental Plaque Diabetes Mellitus Hypoxia Inflammation Inspiration function Leukemia, Myelocytic, Acute Lipoproteins Lung Diseases, Obstructive Lung diseases Metabolic Process, Cellular Myocardial Ischemia Oxidative Stress Patients Rupture Smoke Thrombophilia Thromboxanes confirmation - ResponseLevel oxidation
Content Type	Text
Resource Type	Article