NDLI: Sleep deprivation decreases superoxide dismutase activity in rat hippocampus and brainstem.

Please wait, while we are loading the content...

Sleep deprivation decreases superoxide dismutase activity in rat hippocampus and brainstem.

Content Provider	Semantic Scholar
Author	Ramanathan, Lalini Gulyani, Seema Nienhuis, Robert Siegel, Jerome M.
Copyright Year	2002
Abstract	Sleep deprivation by the disk-over-water technique results in a predictable syndrome of physiological changes in rats. It has been proposed that reactive oxygen species (ROS) may be responsible for some of these effects. A variety of antioxidative enzymes such as superoxide dismutase (SOD) and glutathione peroxidase (GPx) help to regulate the level of ROS. In this study we investigated the effects of prolonged (5-11 days) sleep deprivation on the activities of SOD and GPx as well as the metabolic activity of the mitochondria (using alamar blue) in several brain regions (cortex, hippocampus, hypothalamus, brainstem and cerebellum). We show that prolonged sleep deprivation significantly decreased Cu/Zn-SOD activity in the hippocampus and brainstem, suggesting an alteration in the metabolism of ROS resulting in oxidative stress.
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.semel.ucla.edu/sites/all/files/sleep-research/pubslabcss/Lalini2002.pdf
PubMed reference number	12167758v1
Volume Number	13
Issue Number	11
Journal	Neuroreport
Language	English
Access Restriction	Open
Subject Keyword	Alamar Blue Brain Stem Cerebellum Curcumin GLUTATHIONE PEROXIDASE Hypothalamic structure Metabolic Process, Cellular Oxidative Stress Reactive Oxygen Species Superoxides downregulation of copper, zinc superoxide dismutase activity
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in