The Rat Urinary Bladder as a New Target of Heterocyclic Amine Carcinogenicity: Tumor Induction by 3‐Amino‐l‐methyl‐5H‐pyrido[4,3‐β]indole Acetate

Content Provider	Semantic Scholar
Author	Takahashi, Michihito Toyoda, Kazuhiro Aze, Yoshiya Furuta, Kyoko Mitsumori, Kunitoshi Hayashi, Yuzo
Copyright Year	1993
Abstract	In order to examine the carcinogenicity of 3-amino-1-methyl-5H-pyrido[4,3-b]indole acetate (Trp-P-2), 30 male and 30 female F344 rats were maintained on diet containing 0, 30, or 100 ppm Trp-P-2 for 112 weeks. The overall mean chemical intakes in the 100 ppm and 30 ppm groups were 3.84 and 1.14 mg/kg/day in males, and 4.57 and 1.34 mg/kg/day in females, respectively. Females of the 100 ppm group showed increased mortality in the late period of the study. In the 100 ppm group, significant increases in the incidences of neoplastic lesions were found in the liver, urinary bladder and mammary gland in males, and in the mammary gland, hematopoietic system and clitoral gland in females. Histologically, tumors induced by Trp-P-2 were hepatocellular adenomas, transitional cell tumors (papillomas and carcinomas) of the urinary bladder, fibroadenomas/fibromas of the mammary gland, malignant lymphomas and clitoral gland tumors (adenomas and adenocarcinomas). These results indicate multi-target carcinogenicity of Trp-P-2 in F344 rats and provide evidence that the urinary bladder is also a target for heterocyclic amine action.
Starting Page	852
Ending Page	858
Page Count	7
File Format	PDF HTM / HTML
PubMed reference number	8407549v1
Volume Number	84
Journal	Japanese journal of cancer research : Gann
Language	English
Access Restriction	Open
Subject Keyword	Adenocarcinoma Bladder Tissue Breast Clitoral Gland Clitoris Fibroadenoma Hematopoietic System Hepatocellular Adenoma Heterocyclic Amines Heterocyclic Compounds, 3-Ring Lymphoma Mammary gland Milligram per Kilogram per Day Neoplasms Numerous Papilloma Pineal Gland Neoplasm Transitional Epithelial Cells Tryptophan Urinary Bladder Calculi (disorder) fibroma medroxyprogesterone acetate mg/kg part per million (ppm)
Content Type	Text
Resource Type	Article