NDLI: Ibotenic acid lesions of the substantia nigra pars reticulata ipsilateral to a visual cortical lesion fail to restore visual orienting responses in the cat.

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Ibotenic acid lesions of the substantia nigra pars reticulata ipsilateral to a visual cortical lesion fail to restore visual orienting responses in the cat.

Content Provider	Semantic Scholar
Author	Wallace, Shirley Hastings Rosenquist, Alan C.
Copyright Year	1997
Abstract	Unilateral removal of all known visual cortical areas in the cat renders the animal hemianopic in the contralateral visual field as measured by visual perimetry and other behavioral tests. We have shown that visual orientation behavior can be restored to the previously blind hemifield by destruction of a critical zone in the substantia nigra pars reticulata contralateral to a cortical lesion (Wallace et al., J. Comp. Neurol. 296:222-252, 1990). The model proposed to explain this recovery postulates that damage to the crossed nigrotectal projection disinhibits the superior colliculus ipsilateral to the cortical lesion and this leads to recovery. If disinhibition can account for recovery, then destruction of the uncrossed nigrotectal projection, which is known to exert a tonic inhibition on the superior colliculus, should also result in recovery. We made unilateral visual cortical ablations and ipsilateral ibotenic acid lesions of the substantia nigra pars reticulata. Visual orienting behavior was assessed in animals for a period of 4 to 31 weeks. Contrary to the prediction of the model, we failed to observe a recovery of visual orienting behavior in the blind hemifield in any of 23 animals.
Starting Page	596
Ending Page	610
Page Count	15
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://babies.umb.edu/Babylab/WebPage/pages/research/article/Ciaramitaro_et_al-1997-The_Journal_of_Comparative_Neurology.pdf
PubMed reference number	9007195v1
Volume Number	377
Issue Number	4
Journal	The Journal of comparative neurology
Language	English
Access Restriction	Open
Subject Keyword	Area striata structure Cerebral cortex Corpora quadrigemina, superior colliculus Ibotenic Acid Perimetry Social disinhibition Substantia nigra structure Thioctic Acid pars reticulata of substantia nigra physical hard work
Content Type	Text
Resource Type	Article

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