NDLI: Comparative genomic analysis of hyperthermophilic archaeal Fuselloviridae viruses.

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Comparative genomic analysis of hyperthermophilic archaeal Fuselloviridae viruses.

Content Provider	Semantic Scholar
Author	Wiedenheft, Blake Stedman, Kenneth M. Gleske, Anne-Kathrin Zoeller, Luisa Douglas, Trevor Young, M.
Copyright Year	2004
Abstract	The complete genome sequences of two Sulfolobus spindle-shaped viruses (SSVs) from acidic hot springs in Kamchatka (Russia) and Yellowstone National Park (United States) have been determined. These nonlytic temperate viruses were isolated from hyperthermophilic Sulfolobus hosts, and both viruses share the spindle-shaped morphology characteristic of the Fuselloviridae family. These two genomes, in combination with the previously determined SSV1 genome from Japan and the SSV2 genome from Iceland, have allowed us to carry out a phylogenetic comparison of these geographically distributed hyperthermal viruses. Each virus contains a circular double-stranded DNA genome of approximately 15 kbp with approximately 34 open reading frames (ORFs). These Fusellovirus ORFs show little or no similarity to genes in the public databases. In contrast, 18 ORFs are common to all four isolates and may represent the minimal gene set defining this viral group. In general, ORFs on one half of the genome are colinear and highly conserved, while ORFs on the other half are not. One shared ORF among all four genomes is an integrase of the tyrosine recombinase family. All four viral genomes integrate into their host tRNA genes. The specific tRNA gene used for integration varies, and one genome integrates into multiple loci. Several unique ORFs are found in the genome of each isolate.
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.rcn.montana.edu/Publications/Pdf/2004/Comparative%20genomic%20analysis%20of%20hyperthermophilic%20a.pdf
PubMed reference number	14747560v1
Volume Number	78
Issue Number	4
Journal	Journal of virology
Language	English
Access Restriction	Open
Subject Keyword	Acids DNA, Double-Stranded Databases Frame (physical object) Fuselloviridae Fusellovirus Hot Springs Integrase Natural Springs O'nyong-nyong Virus Open Reading Frames Reading Frames (Nucleotide Sequence) Sulfolobus virus 1 Tacrolimus Binding Proteins Tyrosine Viral Genome recombinase
Content Type	Text
Resource Type	Article

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