Synthesis, Antibacterial, Docking and Anticancer Evaluation of N-Substituted Benzoyl Derivatives

Content Provider	Semantic Scholar
Author	Arthi, P. Nivedhana Shobana, Sutha Srinivasan, Pappu Rahiman, Aziz Kalilur
Copyright Year	2014
Abstract	A series of N-benzoylated ligands incorporating three different benzoyl groups 2,2’-(benzoyliminodiethylene)-4substituted phenols (L), 2,2’-(4-nitrobenzoyliminodiethylene)-4-substituted phenols (L) and 2,2’-(3,5dinitrobenzoyliminodiethylene)-4-substituted phenols (L) were synthesized and characterized by IR, H NMR, C NMR and mass spectroscopy. The In vitro antibacterial activity of investigated ligands were tested against human pathogenic bacteria such as four Gram (–) Enterococcus faecalis, Pseudomonas aeruginosa, Staphylococcus aureus, Vibrio cholera, Vibrio harveyi and two Gram (+) Staphylococcus aureus, Streptococcus mutans. Furthermore, docking studies were undertaken to gain insight into the possible binding mode of these compounds with the binding site of the topoisomerase II (PDB: 4FM9) enzyme which is involved in DNA superhelicity and chromosome seggregation. The Nbenzoylated derivatives L 7, 8 have significant anticancer activity as Topoisomerase inhibitors. The ligands L and L were tested for their anticancer activity against human liver adenocarcinoma (HepG2) cell line with the MTT assay.
Starting Page	241
Ending Page	252
Page Count	12
File Format	PDF HTM / HTML
DOI	10.13160/ricns.2014.7.4.241
Volume Number	7
Alternate Webpage(s)	http://ocean.kisti.re.kr/downfile/volume/ricns/GCOGBD/2014/v7n4/GCOGBD_2014_v7n4_241.pdf
Alternate Webpage(s)	https://doi.org/10.13160/ricns.2014.7.4.241
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article