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Interleukin-6 production in posttransplant lymphoproliferative disease.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Tosato, Giovanna Jones, Kirk Breinig, M. K. McWilliams, Harry Mcknight, J. L. |
| Copyright Year | 1993 |
| Abstract | IL-6, a multifunctional cytokine produced by monocytes, fibroblasts, and endothelial cells, promotes the growth of EBV-immortalized B cells in vitro and renders these cells tumorigenic in athymic mice. In the present study, serum/plasma IL-6 bioactivity was found to be abnormally elevated, albeit transiently, in 17 of 18 solid organ transplant recipients with posttransplant lymphoproliferative disease (PTLD), with a mean maximal level of 196.7 U/ml. This represents a 16.4 increase above the normal mean (11.3 U/ml). In contrast, only 3 of 10 solid organ transplant recipients with uncomplicated courses posttransplant had abnormally elevated serum/plasma IL-6 bioactivity (mean maximal level 41.4 U/ml, P = 0.0007). When transferred to single cell culture, the 11 PTLD tissues produced 640 to 1.25 x 10(6) IL-6 U/ml in the culture supernatant, with a mean maximal level of 35,025 IL-6 U/ml. Cell separation experiments demonstrated that the adherent cells, identified as non-B cells, were the principal source of IL-6 production in vitro by PTLD tissue. Control cultures of inflammatory lymphoid tissue negative for lymphoproliferative disease as well as of PBL from patients with acute EBV-induced infectious mononucleosis consistently produced < 10 IL-6 U/ml. Thus, IL-6 is produced at high levels by PTLD tissues and may play a critical role in the pathogenesis of PTLD. |
| Starting Page | 1 |
| Ending Page | 2 |
| Page Count | 2 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://dm5migu4zj3pb.cloudfront.net/manuscripts/116000/116523/JCI93116523.pdf |
| PubMed reference number | 8514888v1 |
| Volume Number | 91 |
| Issue Number | 6 |
| Journal | The Journal of clinical investigation |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Body tissue Cell Culture Techniques Epstein-Barr Virus Immortalization Infectious Mononucleosis Interleukin-6 Leukemia, B-Cell Lymphoid Tissue Lymphoproliferative Disorders Patients Post-transplant lymphoproliferative disorder Solid organ Transplant Recipients Transplanted organ cytokine |
| Content Type | Text |
| Resource Type | Article |
