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Changes in pulmonary function in patients with ulcerative colitis.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Mohamed-Hussein, Aliaë A. R. Mohamed, Nadia Abdalla Ibrahim, Mahrous Abdel Basset |
| Copyright Year | 2007 |
| Abstract | OBJECTIVES Information on the occurrence and frequency of pulmonary involvement in patients with ulcerative colitis (UC) is inconsistent. Some authors reported pulmonary impairment with UC by standard pulmonary function tests (PFTs) and documented a reduced diffusing capacity for carbon monoxide (DLCO) especially in patients with active disease, whereas others could not detect differences in routine PFTs between UC patients and controls. AIM The aim of this prospective study was to determine the frequency and type of pulmonary dysfunction in patients with UC with respect to disease activity. Furthermore, to evaluate the influence of smoking, nutritional status, sputum cytology and sulphasalazine therapy on PFT parameters. PATIENTS AND METHODS Twenty-six patients with UC (20 with active disease, 6 inactive) and 16 age and sex matched healthy controls were investigated with respect to the following pulmonary function tests, forced vital capacity (FVC), forced expiratory volume in the 1s (FEV(1)%) and their ratio (FEV(1)/FVC) and forced expiratory flow 25-75% (FEF25-75%) as well as oxygen saturation. For UC patients, colonoscopy and biopsy were done. Disease activity was assessed by Truelove index for UC. Induced sputum was sampled for cytology. Smoking habit, body mass index (BMI) and medications were recorded. RESULTS Fifteen out of 26 patients with UC (57.6%) exhibited at least one pathological pulmonary function test (<80% of predicted value). Small airway obstruction was reported in the 15 patients, restrictive dysfunction in 30.7% and obstructive dysfunction in 11.5%. The impairment of PFTs was significant and more pronounced in patients with active disease, FVC (-14% of predicted), FEV(1) (-9% of predicted) and FEF25-75% (-32% of predicted), P<0.01, 0.05 and 0.01, respectively. There was no significant influence of smoking and medications on PFTs. CONCLUSIONS UC patients show significantly decreased lung function tests in comparison to healthy controls. The impairment in active disease exceeded that during the remission. Early recognition is important, as they can be strikingly steroid responsive. |
| Starting Page | 1405 |
| Ending Page | 1407 |
| Page Count | 3 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.aun.edu.eg/reserches_files/15943.pdf |
| PubMed reference number | 17049827v1 |
| Volume Number | 101 |
| Issue Number | 5 |
| Journal | Respiratory medicine |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Airway Obstruction Carbon Monoxide Diffusing Capability Test Document completion status - Documented Eighty Expiration, function Forced expiratory volume procedure Idiopathic Pulmonary Fibrosis Lung Diseases, Obstructive Oxygen saturation test result Patients Physical Inactivity Pulmonary Subvalvular Stenosis Pulmonary Valve Insufficiency Respiratory Depression Respiratory physiology Smoke Sputum Cytology Screening Status Epilepticus Steroids Sulfasalazine Supernumerary maxillary right third molar Ulcer Ulcerative Colitis bentiromide |
| Content Type | Text |
| Resource Type | Article |
