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Association between ovarihysterectomy and feline mammary carcinoma.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Overley, Beth Shofer, Frances Goldschmidt, Michael H. Sherer, Dave Sorenmo, Karin U. |
| Copyright Year | 2005 |
| Abstract | The etiopathogenesis of feline mammary carcinoma is not well understood. Although putative, risk factors include breed, reproductive status, and regular exposure to progestins. An association between age at ovarihysterectomy (OHE) and mammary carcinoma development has not been established. Therefore, a case-control study was performed to determine the effects of OHE age, breed, progestin exposure, and parity on feline mammary carcinoma development. Cases were female cats diagnosed with mammary carcinoma by histological examination of mammary tissue. Controls were female cats not diagnosed with mammary tumors selected from the same biopsy service population. Controls were frequency matched to cases by age and year of diagnosis. Questionnaires were sent to veterinarians for 308 cases and 400 controls. The overall questionnaire response rate was 58%. Intact cats were significantly overrepresented (odds ratio [OR] 2.7, confidence interval [CI] = 1.4-5.3, P < .001) in the mammary carcinoma population. Cats spayed prior to 6 months of age had a 91% reduction in the risk of mammary carcinoma development compared with intact cats (OR 0.9, CI = 0.03-0.24). Those spayed prior to 1 year had an 86% reduction in risk (OR 0.14, CI = 0.06-0.34). Parity did not affect feline mammary carcinoma development, and too few cats had progestin exposure to determine association with mammary carcinoma. Results indicate that cats spayed before 1 year of age are at significantly decreased risk of feline mammary carcinoma development. |
| Starting Page | S529 |
| Ending Page | S529 |
| Page Count | 1 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://nebula.wsimg.com/1dc00cf29aad47e76cd3f57b6490480e?AccessKeyId=A355568981F7DB010C75&alloworigin=1&disposition=0 |
| PubMed reference number | 16095174v1 |
| Volume Number | 19 |
| Issue Number | 4 |
| Journal | Journal of veterinary internal medicine |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Animal Mammary Neoplasms Breast Carcinoma Breeding Bronchioloalveolar Adenocarcinoma Confidence Intervals Mammary Gland Parenchyma Noninfiltrating Intraductal Carcinoma Progestins Reproduction |
| Content Type | Text |
| Resource Type | Article |
