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Evaluation of dexmedetomidine versus propofol sedation therapy in mechanically ventilated cardiac surgery patients : a systematic review and meta-analysis of randomized controlled trials and observational studies
| Content Provider | Semantic Scholar |
|---|---|
| Author | Chang, Liuhui Fang, Hongwei Wang, Chen Zhu, Jiang Li, Ming Min Wang, Xiangrui Xu, Youjia |
| Copyright Year | 2016 |
| Abstract | Background: During mechanical ventilation, adequate sedation is a vital factor after cardiac surgery; dexmedetomidine is applied to provide a better efficacy of sedation therapy. However, the prognosis is still controversial in clinical. This meta-analysis aims to compare the effects of dexmedetomidine with propofol administration for MV cardiac surgery patients. Methods: We searched multiple electronic databases including PubMed, Embase, Google Scholar and The Cochrane Library and Cochrane Central Register of Controlled Trials, and the results were updated to July 2015. All statistical analysis was performed by Review Manager, and the Cochrane Collaboration’s software was used for preparation and maintenance of Cochrane systematic reviews. Results: Eight trials (three RCTs and five observational studies of 1392 patients) were included, with a sample size ranging from 56 to 582. Pooled analysis suggested that dexmedetomidine had no correlation with decreased duration in MV among cardiac surgery patients in RCTs (WMD: 0.41 D; 95% CI: -1.58-0.76; P = 0.24), but statistically reduced the duration of MV in the observational studies (WMD: -3.80 D; 95% CI: -5.48--2.11; P = 0.15). No statistically significant shorter length of ICU was associated with dexmedetomidine in cardiac surgery patients in two RCTs (WMD: -0.48 D; 95% CI: -1.55-0.59; P = 0.006). Conclusions: Dexmedetomidine has an indispensable role in achieving effective sedation in cardiac surgery patients. Current evidences demonstrate that dexmedetomidine decreases the duration of MV in cardiac surgery patients. Nevertheless, most results relying on the data from observational studies only might cause the selection bias. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.ijcem.com/files/ijcem0024616.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
