NDLI: Steady-state kinetics and analgesic effect of oral morphine in cancer patients

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Steady-state kinetics and analgesic effect of oral morphine in cancer patients

Content Provider	Semantic Scholar
Author	Säwe, Juliette Dahlström, Bengt E. Rane, Anders
Copyright Year	2004
Abstract	SummaryThe steady-state kinetics of morphine given as tablets and solution were compared in 7 cancer patients with chronic pain. There was no accumulation of morphine (20–40 mg) when repeatedly administered every 4 to 6 h. The mean steady-state concentration of morphine during the dose interval varied between 5.9 and 68.4 ng/ml (20.7–240 nmol/l), and was linearly related to the daily dose of morphine. There were no significant differences between the tablets and the solution of morphine with regard to relative oral bioavailability or peak concentration. The time-to-maximum plasma concentrations was significantly longer for the tablets. The pain score profile, assessed by a visual analogue scale during a dose interval, showed a similar pattern after the two oral formulations of morphine. No significant linear relationship between the scores and the plasma concentrations of morphine was observed.
Starting Page	537
Ending Page	542
Page Count	6
File Format	PDF HTM / HTML
DOI	10.1007/BF00609900
PubMed reference number	6861871
Journal	Medline
Volume Number	24
Alternate Webpage(s)	https://page-one.springer.com/pdf/preview/10.1007/BF00609900
Alternate Webpage(s)	https://doi.org/10.1007/BF00609900
Journal	European Journal of Clinical Pharmacology
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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