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Highly bright water-soluble silica coated quantum dots with excellent stability.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Ma, Yunfei Ma, Shijian Zhong, Xinhua |
| Copyright Year | 2014 |
| Abstract | Silica coating via a Stöber method is an effective route to render luminescent quantum dots (QDs) with great biocompatibility, low toxicity and water-solubility for bioapplications. However, the bottleneck in this route is the access of highly luminescent, colloidally stable QD dispersion in alcoholic solution. Herein, we report a facile route based on the Stöber method for the synthesis of isolated silica coated QDs (QD@SiO2) with high emission efficiencies, tunable small size (less than 30 nm) and excellent stability. Prior to silica coating, the initial oil-soluble QDs were made dispersible in alcohol-water media by replacing the native hydrophobic ligands with adenosine 5'-monophosphate (AMP). Then, 3-mercaptopropyl-trimethoxysilane (MPS) was introduced to serve as silane nucleation primers. Finally, a silica shell with controllable thickness was obtained on the QD surface by hydrolysis/condensation of tetraethyl orthosilicate (TEOS). Remarkably, the resultant QD@SiO2 had nearly the same high luminescent efficiency (50-65%) as that of initial oil-soluble QDs and exhibited excellent long-term photo and colloidal stability in harsh environments (pH range of 3-13, saturated NaCl solution and thermal treatment at 100 °C). It was demonstrated that the cytotoxicity of the resultant QD@SiO2 was significantly diminished. Moreover, the QD@SiO2 conjugated with folic acid exhibits high specific binding toward receptor-positive Hela cells over receptor-negative A549 cells, indicating the potential of our obtained QD@SiO2 as robust biomarkers in cells due to their chemical processibility and low cytotoxicity. |
| Starting Page | 5043 |
| Ending Page | 5051 |
| Page Count | 9 |
| File Format | PDF HTM / HTML |
| DOI | 10.1039/C4TB00458B |
| PubMed reference number | 32261837 |
| Journal | Medline |
| Volume Number | 2 |
| Issue Number | 31 |
| Alternate Webpage(s) | https://pubs.rsc.org/en/content/getauthorversionpdf/C4TB00458B |
| Alternate Webpage(s) | http://www.rsc.org/suppdata/tb/c4/c4tb00458b/c4tb00458b1.pdf |
| Journal | Journal of materials chemistry. B |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
