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How safe are anti-rheumatic drugs during pregnancy?
| Content Provider | Semantic Scholar |
|---|---|
| Author | Østensen, Monika Förger, Frauke |
| Copyright Year | 2013 |
| Abstract | Rheumatic diseases may be active during pregnancy necessitating drug treatment in order to control maternal disease activity and ensure a successful pregnancy outcome. The present literature survey of the last 2 years does not profoundly change the recommendations given in recent reviews: the teratogenic drugs cyclophosphamide, methotrexate, mycophenolate mofetil, and biologics without or with few pregnancy data must be withdrawn before a planned pregnancy. Leflunomide has up to date not shown to be a human teratogen. Drugs that can be used throughout pregnancy include corticosteroids, sulfasalazine, antimalarials, cyclosporine, tacrolimus and azathioprine. Among biological drugs extended pregnancy experience exists only for TNF-inhibitors. The effect of immunosuppressive drugs and biologics on male reproductive function is only partly known. |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/j.coph.2013.03.004 |
| Alternate Webpage(s) | http://insanemedicine.com/wp-content/uploads/2016/06/How-safe-are-anti-rheumatic-drugs-during-pregnancy.pdf |
| PubMed reference number | 23522967 |
| Alternate Webpage(s) | https://doi.org/10.1016/j.coph.2013.03.004 |
| Journal | Medline |
| Volume Number | 13 |
| Issue Number | 3 |
| Journal | Current opinion in pharmacology |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
