Blockade of dopamine D2, but not of D1 receptors in the rat globus pallidus induced Fos-like immunoreactivity in the caudate-putamen, substantia nigra and entopeduncular nucleus

Content Provider	Semantic Scholar
Author	Hauber, Wolfgang Lutz, Sylke
Copyright Year	1999
Abstract	In the present study, we investigated Fos-like immunoreactivity (FLI) evoked by pallidal dopamine (DA) D1 and D2 receptor blockade in the caudate-putamen (CPu), substantia nigra (SN) and entopeduncular nucleus (EP), i.e. major target areas of pallidal efferents. Results demonstrate that infusion of the selective D1 antagonist SCH23390 (1 and 4 microg/0.5 microl) into the globus pallidus (GP) did not induce FLI in the CPu, SN and EP. In contrast, intrapallidal infusion of a low dose of the selective D2 antagonist S(-)-sulpiride (15 microg/0.5 microl) induced FLI restricted to the CPu. A higher dose of intrapallidal S(-)-sulpiride (25 microg/0.5 microl) induced FLI in the CPu as well as in the SN and EP. These findings add further evidence to notion that the GP plays a central role in the basal ganglia circuitry and demonstrate an involvement of extrastriatal DA via D2 receptors.
Starting Page	73
Ending Page	76
Page Count	4
File Format	PDF HTM / HTML
DOI	10.1016/S0304-3940(99)00548-0
Alternate Webpage(s)	https://api.elsevier.com/content/article/pii/S0304394099005480
Alternate Webpage(s)	https://www.sciencedirect.com/science/article/pii/S0304394099005480?dgcid=api_sd_search-api-endpoint
PubMed reference number	10477105
Alternate Webpage(s)	https://doi.org/10.1016/S0304-3940%2899%2900548-0
Journal	Medline
Volume Number	271
Journal	Neuroscience Letters
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article