NDLI: Coordinating changes in cell adhesion and phenotype during EMT-like processes in cancer

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Coordinating changes in cell adhesion and phenotype during EMT-like processes in cancer

Content Provider	Semantic Scholar
Author	Gavert, Nancy Ben-Ze'ev, Avri
Copyright Year	2010
Abstract	Understanding the progression of a primary cancer to the metastatic stage has been the focus of extensive research for years. Commonly accepted concepts in this process (i.e., that of genetic instability and loss of normal cellular constraints on growth and motility) are well established. Other important paradigms, such as the necessary change from an epithelial cell phenotype displaying cell-cell adhesions to a singular and motile mesenchymal-like cell phenotype (possibly derived from a stem cell-like cell) via a process similar to epithelial to mesenchymal transition (EMT), are less well understood. In this review we will address studies linking EMT and cancer stem cells during cancer development and observations that are challenging these concepts.
Starting Page	1766
Ending Page	1767
Page Count	2
File Format	PDF HTM / HTML
PubMed reference number	21283595
DOI	10.3410/b2-86
Journal	F1000 biology reports
Volume Number	2
Alternate Webpage(s)	http://f1000researchdata.s3.amazonaws.com/f1000reports/files/9002/2/86/article.pdf
Alternate Webpage(s)	https://doi.org/10.3410/B2-86
Language	English
Access Restriction	Open
Subject Keyword	Cell Adhesion Primary malignant neoplasm Singular Stem cells epithelial to mesenchymal transition
Content Type	Text
Resource Type	Article

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