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Facile Fabrication of Aggregation-induced Emission Based Red Fluorescent Organic Nanoparticles for Cell Imaging
| Content Provider | Semantic Scholar |
|---|---|
| Author | Zhang, Xi-Qi Zhang, Xiao-Yong Yang, Bin |
| Copyright Year | 2014 |
| Abstract | A cyano-substituted diarylethlene derivative aggregation-induced emission (AIE) dye with two amino end-groups and 4,4'-(hexafluoroisopropylidene)diphthalic anhydride were facilely incorporated into red fluorescent organic nanoparticles (FONs) via room temperature anhydride ring-opening polymerization under an air atmosphere. These obtained RO-HFDA FONs were characterized by a series of techniques including gel permeation chromatography, Fourier transform infrared spectroscopy, size distribution and zeta potential measurements, UV-Vis absorption spectrum, fluorescent spectroscopy and transmission electron microscopy. Biocompatibility evaluation and cell uptake behavior of RO-HFDA FONs were further investigated to explore their potential biomedical application. We demonstrated that such FONs showed high water dispersibility, stable uniform spherical morphology (150−200 nm), broad excitation band (350−605 nm), intense red fluorescence (627 nm) and excellent biocompatibility, making them promising for cell imaging applications. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.escience.cn/system/download/69062 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |