Loading...
Please wait, while we are loading the content...
Thymic neuroendocrine tumor (thymic carcinoid): a clinicopathologic study in 15 patients.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Fukai, Ichiro Masaoka, Akira Fujii, Yoshitaka Yamakawa, Yasushi Yokoyama, Takeyoshi Murase, Takayuki Eimoto, Tadaaki |
| Copyright Year | 1999 |
| Abstract | BACKGROUND Thymic neuroendocrine tumor (carcinoid tumor) is rare, and prognosis for patients with this tumor has been difficult to predict. METHODS The medical records of 15 patients were reviewed, and the patients were classified according to tentative TNM classification and histologic grade. RESULTS Ten (66.7%) of 15 patients were male. Lymph node metastases were identified in 9 (60%) of 15 patients at the time of resection. There were one grade 1, nine grade 2, and five grade 3 tumors. Total resection was possible in 13 patients. Distant metastases developed in 10 (76.9%) of these 13 patients, although no local recurrence developed. Of these 10 patients, 6 died of distant metastases 5 to 25 months after the recurrence. Three patients are still alive, with metastases to the bone, spleen, and pleura 1 to 24 months after the diagnosis of recurrence. Two patients are presently tumor free (T1N0, grade 3 and T3N2, grade 2), but only 1 has survived beyond 5 years. CONCLUSIONS Thymic neuroendocrine tumor must be regarded as a malignant neoplasm that is prone to metastasize to mediastinal lymph nodes and to distant sites, even after total excision. Neither T and N classification nor histologic grade has been successful in predicting the outcome of a patient with this tumor. More aggressive management, including adjuvant therapies and reexcision of subsequent tumors, may result in increased survival. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://thymic.org/uploads/mainpdf/208.pdf |
| PubMed reference number | 10086551v1 |
| Volume Number | 67 |
| Issue Number | 1 |
| Journal | The Annals of thoracic surgery |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Anatomic Node Bone Tissue Cessation of life Classification Excision Histopathologic Grade Lymphadenopathy Malignant Neoplasms Mediastinal lymph node group Mediastinum Neoplasm Metastasis Neuroendocrine Tumors Neurosecretory Systems Patients Pharmaceutical Adjuvants Pleura Spleen Tissue Therapeutic procedure Thymic Carcinoid Tumor lymph nodes pediatric intracranial germ cell brain tumor re-excision |
| Content Type | Text |
| Resource Type | Article |
