NDLI: Protection of Cardiomyocytes from Acute Ischemic Injury by Protein Kinase Cε Expression

Please wait, while we are loading the content...

Protection of Cardiomyocytes from Acute Ischemic Injury by Protein Kinase Cε Expression

Content Provider	Semantic Scholar
Author	Yoo, Jeong-Nam Lee, Soo Hoon Jang, Sun-Ik Kim, Sang-Ok Lee, Kwang-Hee Park, Mina Lim, Tae-Hyung Kwon, Jin-Sook Cho, Myeong-Chan Kim, Young Dae
Copyright Year	2007
Abstract	Background and Objectives:Ischemic injury is the most common and important cause of myocardial damage. Over past decades, a number of studies have identified a protective mechanism known as ischemic preconditioning, which can block or delay cell death from ischemic injury. Protein kinase C (PKC), especially theeisoform has been proposed as a key factor in the signaling pathway of ischemic preconditioning. However, whether PKCe expression in cardiomyocytes can offer such protection from acute ischemia has not been explored. Materials and Methods: To demonstrate a direct effect of PKCe expression, a lentiviral vector system was established. Using the lentiviral vector, PKCe was introduced to neonatal rat ventricular myocytes (NRVM) cultured under ischemic conditions, and also to adult rat myocardium subject to left coronary artery ligation. Results:Compared to control, PKCe ex- pression in cultured NRVM under ischemia resulted in preserved cell density and morphology, and a reduction in cell death (77.6±12.8% vs 58.1±7.2%, p<0.05). In adult rats, the infarcted area after coronary artery ligation was markedly reduced in myocardium injected with PKCe vector compared to control (11.4±5.3% vs 20.5± 11.3%, p<0.01). Conclusion:These results provide direct evidence that PKCe is a central player in protection against cell death from acute ischemia. (Korean Circulation J 2007;37:327-333)
Starting Page	327
Ending Page	333
Page Count	7
File Format	PDF HTM / HTML
DOI	10.4070/kcj.2007.37.7.327
Volume Number	37
Alternate Webpage(s)	https://synapse.koreamed.org/Synapse/Data/PDFData/0054KCJ/kcj-37-327.pdf
Alternate Webpage(s)	https://doi.org/10.4070/kcj.2007.37.7.327
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in