NDLI: Fibre distribution in the lungs and pleura of subjects with asbestos related diffuse pleural fibrosis.

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Fibre distribution in the lungs and pleura of subjects with asbestos related diffuse pleural fibrosis.

Content Provider	Semantic Scholar
Author	Stephens, Matthew Griffiths, David Mervyn Blight, B. J.
Copyright Year	1991
Abstract	The lungs from 13 cases of diffuse pleural fibrosis associated with a history of exposure to asbestos were examined. Samples were taken from the visceral pleura and central and subpleural zones of the lungs for histopathological and mineralogical studies. The fibre type, size, and number were estimated for each of these regions by transmission electron microscopy and energy dispersive x ray analysis. Amphibole fibre counts were raised when compared with a non-occupationally exposed group and matched those seen in cases of pleural plaques, mild asbestosis, and mesothelioma. A wide case to case variation of distribution was seen. No significant difference was apparent between central and subpleural zones, whereas low asbestos counts were found in the pleura; these were mainly short chrysotile fibres. Within the lungs more (45%) of the longer (greater than 4 microns) and thinner (less than 0.25 micron) amphibole fibres were retained in keeping with other studies implicating such fibre profiles in the pathogenesis of asbestos related disease.
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://oem.bmj.com/content/oemed/48/11/762.full.pdf
PubMed reference number	1659443v1
Volume Number	48
Issue Number	11
Journal	British journal of industrial medicine
Language	English
Access Restriction	Open
Subject Keyword	Asbestos Asbestosis Chrysotile Fibrosis Lung Mesothelioma Micron Parkinson Disease Pleural effusion disorder Roentgen Rays Senile Plaques Tissue fiber Transmission Electron Microscopy Visceral pleura
Content Type	Text
Resource Type	Article

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