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Automated Breast Volumetric Sonography Compared with Magnetic Resonance Imaging in Jewish BRCA 1/2 Mutation Carriers.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Neiman, Osnat Halshtok Erlich, Zippy Friedman, Eitan Rundstein, Arie Shalmon, Anat Servadio, Yael Levy, Miri Sklair |
| Copyright Year | 2016 |
| Abstract | BACKGROUND Automated breast volumetric sonography (ABVS) is a new technology with various possible applications. OBJECTIVES To compare ABVS and breast magnetic resonance imaging (MRI) in the surveillance of women with BRCA1/2 gene mutation carriers. METHODS We conducted a prospective study in Jewish female BRCA1/2 mutation carriers who underwent breast MRI and ABVS. The results of both exams performed 6 months apart or less, and relevant clinical data, were reviewed. The BIRADS results were divided into three subgroups according to subsequent expected management: BIRADS 1-2 (normal study), BIRADS 3 (probably benign finding), and BIRADS 4 and 5 (suspicious findings). BIRADS 0 and 6 scores were excluded from the study. Distribution of ABVS and MRI BIRADS scores were compared using McNemar's test, and concordance was calculated using the Cohen kappa test. RESULTS Overall, 68 women, 40 BRCA1 and 28 BRCA2 mutation carriers, age range 26-69 (mean 44.55 ± 12.1 years), underwent 79 paired ABVS and MRI examinations. McNemar's test calculations showed no significant difference between MRI and ABVS BIRADS score distribution. Cohen's kappa test resulted in k = 0.158, an agreement that can be described as only "slight agreement" between both modalities. Of 14 discordant cases there was one cancer, revealed by MRI and not by ABVS performed 6 months prior to MRI. CONCLUSIONS ABVS showed slight agreement with MRI in BRCA1/2 mutation carriers. These preliminary results on a small group of healthy high risk patients suggest that the diagnostic abilities of ABVS are inferior to MRI. Further studies encompassing larger groups are needed. |
| Starting Page | 609 |
| Ending Page | 612 |
| Page Count | 4 |
| File Format | PDF HTM / HTML |
| PubMed reference number | 28471621 |
| Journal | Medline |
| Volume Number | 18 |
| Issue Number | 10 |
| Alternate Webpage(s) | https://www.ima.org.il/FilesUpload/IMAJ/0/217/108697.pdf |
| Journal | The Israel Medical Association journal : IMAJ |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
