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Serum Thioredoxin 1 Level Has Close Relation with Myocardial Damage Amount in Acute Myocardial Infarction Patients
| Content Provider | Semantic Scholar |
|---|---|
| Author | Shim, Young Kwang Kim, Jeong-Tae Seong, Mun-Hyuk Kim, Yeon-Jeong Shim, Tae-Jin Kim, Sang Min Lee, Sang Yeub Bae, Jang-Whan Kim, Ki-Seok Hwang, Kyung Kuk Kim, Dong-woon Cho, Myeong Chan |
| Copyright Year | 2012 |
| Abstract | Thioredoxin-1 (Trx-1) is one of important anti-oxidative molecules to overcome the oxidative stress. The aim of the present study is to investigate the clinical relationship between serum concentration of Trx-1 on the pre-percutaneous coronary intervention (prePCI) and myocardial damage amount in the patients with acute myocardial infarction with the culprit lesion in only the left anterior descending artery on coronary angiography (n = 100). Initial value of creatine kinase (CK) was 368.3 ± 531.4 U/L, and MB isoenzyme of CK (CK-MB) level was 22.92 ± 33.8 ng/mL, and cardiac specific troponin T (cTnT) level was 0.61 ± 1.6 ng/mL. Positive correlations were observed between prePCI Trx-1 level and initial CK (P = 0.005, r = 0.281), and cTnT (P < 0.001, r = 0.453), peak CK (P = 0.001, r = 0.316) in all patients, but the statistical relation was observed only in ST segment elevation myocardial infarction (STEMI) patients (P = 0.008, r = 0.329 for initial CK, P = 0.001, r = 0.498 for initial cTnT, P = 0.005, r = 0.349 for peak CK), not in Non-STEMI patients. Conclusively, we consider prePCI serum Trx-1 as a predictor for myocardial damage amount in patients with STEMI. |
| Starting Page | 1162 |
| Ending Page | 1169 |
| Page Count | 8 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://synapse.koreamed.org/Synapse/Data/PDFData/0063JKMS/jkms-27-1162.pdf |
| PubMed reference number | 23091312 |
| Alternate Webpage(s) | https://doi.org/10.3346/jkms.2012.27.10.1162 |
| DOI | 10.3346/jkms.2012.27.10.1162 |
| Journal | Journal of Korean medical science |
| Volume Number | 27 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Acute myocardial infarction Anterior descending branch of left coronary artery Artificial cardiac pacemaker Cardiomyopathies Creatine Kinase MB Isoenzyme Isoenzymes Leukemia, Myelocytic, Acute Myocardial Ischemia Myocardium Oxidative Stress Patients Percutaneous Coronary Intervention ST segment elevation myocardial infarction Thioredoxin 1 Thioredoxins Troponin T, Cardiac Muscle angiogram |
| Content Type | Text |
| Resource Type | Article |
