NDLI: Reconstitution of spontaneous neutralizing antibody response against autologous human immunodeficiency virus during highly active antiretroviral therapy.

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Reconstitution of spontaneous neutralizing antibody response against autologous human immunodeficiency virus during highly active antiretroviral therapy.

Content Provider	Semantic Scholar
Author	Kimura, Tetsuya Yoshimura, Kazuhisa Nishihara, Kumiko Yosuke Matsumi, Shintaro Koito, Atsushi Matsushita, Shuzo
Copyright Year	2002
Abstract	Longitudinal changes in neutralizing antibody responses against autologous human immunodeficiency virus (HIV) type 1 were investigated in 19 chronically infected patients who were undergoing highly active antiretroviral therapy (HAART). Reconstitution of or increase in neutralization activity was observed in 4 of 19 patients during HAART, but neutralization activity was more or less unchanged in most patients. Three of 4 patients with increased neutralization activity had low-level viral rebound ("blips") during HAART. No correlation was found between neutralization activity and HIV-specific CD4+ T cell frequencies. There was a correlation between neutralization activity and CD4+ T cell counts. The reconstituted antibody represented limited cross-reactivity, compared with that of preexisting antibody. Binding activity to monomeric gp120, V2, and V3 peptides was reduced. Both prolonged virus suppression, for CD4+ T cell recovery, and blips, for stimulation of the immune system in vivo, may be required for development of neutralizing antibody in vivo.
Starting Page	53
Ending Page	60
Page Count	8
File Format	PDF HTM / HTML
DOI	10.1086/338099
Alternate Webpage(s)	http://www.caids.kumamoto-u.ac.jp/clinical/page/kimura.pdf
Alternate Webpage(s)	https://oup.silverchair-cdn.com/oup/backfile/Content_public/Journal/jid/185/1/10.1086/338099/2/185-1-53.pdf?Expires=1492501579&Key-Pair-Id=APKAIUCZBIA4LVPAVW3Q&Signature=C8~QSkRzGESPh8OYaKa6fqZnPanHh2fLM1L7HxyAHlxtTae0wBHrl-t12IO8MdMXfRtYlP1Eo68wBhhrswzq5S-TtXp8bwSc79SmLEP3VkMiZ-g8Zz0hAIZ3VwuBMtU8SGCsr~h2Mm9e7StYq-1BKzUQpa82c1rHId3F9zW7HAVZOkYE3ejtwl1NaYI92OT3WV5XBX69ImP6MFPOABB5fZGHSMTByEjnggrHqep6RLtbJywwUL9yUr0EvTuJSV~X6FZ7hcGsLkMZmmDD1eL12vtTTOiTWpAAwIXWvcjQF1ndn2rI2dOdQHnsMKefMi5o0BOgPi1uxv7ThL92fCaomg__
PubMed reference number	11756981
Alternate Webpage(s)	https://doi.org/10.1086/338099
Journal	Medline
Volume Number	185
Issue Number	1
Journal	The Journal of infectious diseases
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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