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C-fos protein expression in the nucleus of the solitary tract correlates with cholecystokinin dose injected and food intake in rats
| Content Provider | Semantic Scholar |
|---|---|
| Author | Zittel, Tilman T. Glatzle, Jörg Kreis, Martin E. Starlinger, Michael Jehle, Ekkehard C. |
| Copyright Year | 1999 |
| Abstract | C-fos protein expression was investigated in the nucleus of the solitary tract (NTS) in response to increasing cholecystokinin (CCK) doses and food intake in rats by counting the number of c-fos protein positive cells in the NTS. C-fos protein expression in the NTS dose-dependently increased in response to CCK, the lowest effective dose being 0.1 microg/kg. The ED(50) for c-fos protein expression in the NTS in response to CCK was calculated to be 0.5 to 1.8 microg/kg, depending on the anatomical level of the NTS investigated. Food intake increased c-fos protein expression in the NTS, the maximum number of c-fos protein positive cells being reached at 90 min after the start of food intake. Regression analysis identified a positive correlation between c-fos protein expression and the amount of food intake. Our data indicate that subpopulations of the NTS that are activated by CCK or food intake are involved into the short-term regulation of food intake and the neural control of feeding by the caudal brainstem. |
| Starting Page | 1 |
| Ending Page | 11 |
| Page Count | 11 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/S0006-8993(99)01842-9 |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/S0006899399018429 |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/S0006899399018429?dgcid=api_sd_search-api-endpoint |
| PubMed reference number | 10536208 |
| Alternate Webpage(s) | https://doi.org/10.1016/S0006-8993%2899%2901842-9 |
| Journal | Medline |
| Volume Number | 846 |
| Journal | Brain Research |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
