NDLI: Dose-Dependent Effect of Coriander ( Coriandrum Sativum L . ) and Fennel ( Foeniculum Vulgare M . ) on Lead Nephrotoxicity in Rats

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Dose-Dependent Effect of Coriander ( Coriandrum Sativum L . ) and Fennel ( Foeniculum Vulgare M . ) on Lead Nephrotoxicity in Rats

Content Provider	Semantic Scholar
Author	El-Masry, Shimaa Ali, Hanem Abdel-Sabour El-Sheikh, Nora M. Awad, Safaa Mostafa
Copyright Year	2016
Abstract	Nephrotoxicity is a complication due to the effect of some toxic chemicals on kidneys. Current study planned to screen the effect of coriander and fennel aqueous seeds extracts on lead-induced nephrotoxicity. Seventy-two adult male rats were equally divided to 6 groups: group (1) normal control, group (2) leadtoxicated rats were received 50 mg/kg b.wt of lead acetate by gastric tube daily, groups (3-6) were leadtoxicated and administered aqueous seeds extracts of coriander (250 and 500 mg/kg body weight/day) and fennel (100 and 150 mg/kg body weight/day), respectively. Lead-induced renal damage was evidenced by a significant elevation of serum and renal lead with reduction of serum delta amino levulinic acid dehydratase activity. Renal dysfunction was diagnosed by a significant elevation of kidney function tests accompanied with reduction in creatinine clearance. Results evidenced a significant increase of serum sodium and potassium concentrations and their depletion in urine. Renal oxidant-antioxidant balance was disturbed which evidenced by significant increase in renal malondialdehyde and nitric oxide and significant decrease in renal reduced glutathione, catalase, glutathione-S-transferase and superoxide dismutase activity. Treatment with coriander and fennel seeds extracts exerted a significant improvement of most of the biochemical parameters compared to lead group.
File Format	PDF HTM / HTML
DOI	10.20431/2349-0365.0406006
Alternate Webpage(s)	https://www.arcjournals.org/pdfs/ijrsb/v4-i6/6.pdf
Alternate Webpage(s)	https://doi.org/10.20431/2349-0365.0406006
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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