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Distribution of neurokinin B in rat spinal cord and peripheral tissues: Comparison with neurokinin A and substance P and effects of neonatal capsaicin treatment
| Content Provider | Semantic Scholar |
|---|---|
| Author | Moussaoui, Saliha Prado, N. Le Bonici, Bruno Faucher, Didier Garret, Claude |
| Copyright Year | 1992 |
| Abstract | In the present study, highly specific radioimmunoassays were developed and used to measure neurokinin B, neurokinin A and substance P in the rat spinal cord and various peripheral tissues. The results are as follows. (1) Neurokinin B and neurokinin A were distributed all along the rostrocaudal axis of the spinal cord, as is substance P, and were more concentrated in the dorsal than in the ventral region. (2) Substance P was more abundant in the central and peripheral nervous tissues than neurokinin A, while in certain peripheral organs, neurokinin A was more abundant than substance P. In the spinal cord, neurokinin B concentrations were lower than those of the other two tachykinins. (3) In contrast to neurokinin A and substance P, neurokinin B was not detected in any of the peripheral tissues examined. (4) Capsaicin treatment reduced by half neurokinin A and substance P concentrations in the dorsal region of the spinal cord, the dorsal root ganglia and the sciatic nerve, but was without effect on neurokinin B concentrations in the spinal cord. Neurokinin A, like substance P, may therefore have an important function in the transmission of sensory information, particularly in nociceptive transmission from the periphery to the spinal cord and in peripheral neurogenic inflammation. In contrast, since neurokinin B was not found in the sensory neurons, it is not likely to have these functions, but may perhaps control them. |
| Starting Page | 969 |
| Ending Page | 978 |
| Page Count | 10 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/0306-4522(92)90285-A |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/030645229290285A |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/030645229290285A?dgcid=api_sd_search-api-endpoint |
| PubMed reference number | 1378579 |
| Alternate Webpage(s) | https://doi.org/10.1016/0306-4522%2892%2990285-A |
| Journal | Medline |
| Volume Number | 48 |
| Journal | Neuroscience |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
