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CD 8 + T cells from acute multiple sclerosis patients display selective increase of adhesiveness in brain venules : a critical role for P-selectin glycoprotein ligand-1
| Content Provider | Semantic Scholar |
|---|---|
| Author | Battistini, Luca Piccio, Laura Rossi, Barbara Bach, Simona Galgani, Simona Gasperini, Claudio Ottoboni, Linda Ciabini, Donatella Caramia, Maria Donatella Bernardi, Giorgio Laudanna, Carlo Scarpini, Elio McEver, Rodger P. Borsellino, Giovanna |
| Copyright Year | 2003 |
| Abstract | Multiple Sclerosis (MS) is considered an autoimmune inflammatory disease of the central nervous system. We compared for the first time the adhesiveness of CD4 and CD8 lymphocytes from acute, non-treated patients with the relapsing remitting form of the disease (RRMS) and from healthy donors under physiological conditions. We show that in patients with RRMS CD8, but not CD4, T cells display increased rolling and arrest in inflamed murine brain venules. Moreover, CD8, but not CD4, lymphocytes from MS patients show increased rolling on P-selectin in vitro. Anti-P-selectin glycoprotein ligand-1 (PSGL-1) antibodies dramatically block the recruitment of CD8 cells from MS patients in brain vessels, suggesting that PSGL-1 represents a novel pharmaceutical target which may be exploited to block the selective entrance of CD8 cells during early inflammation. VCAM-1, but not PSGL-1, is critical for the adhesion of CD4 cells from MS patients, highlighting a fundamental dichotomy in the mechanisms governing the recruitment of lymphocyte subsets in RRMS. Importantly, seven-colour FACS analysis together with functional data indicates that a large fraction of CD8 cells from MS patients display the characteristics of memory effector phenotype. In conclusion, our results show that CD8, but not CD4, T cells from patients with RRMS in the acute phase of the disease display increased ability to be recruited in inflamed brain venules. gabriela.constantin@univr.it For personal use only. on October 17, 2017. by guest www.bloodjournal.org From |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.bloodjournal.org/content/bloodjournal/early/2003/02/20/blood-2002-10-3309.full.pdf?sso-checked=true |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Adhesiveness BCS-FACS Blood Vessel CNS disorder Cerebrovascular system In Vitro [Publication Type] Lymphocyte Subset Multiple Sclerosis P-Selectin Patients Selectins Structure of venule Vascular Cell Adhesion Molecule-1 inflammatory disease |
| Content Type | Text |
| Resource Type | Article |
