NDLI: El papel de la membrana mitocondrial externa en el control del metabolismo energético celular

Please wait, while we are loading the content...

El papel de la membrana mitocondrial externa en el control del metabolismo energético celular

Content Provider	Semantic Scholar
Author	Lemeshko, Viktor V.
Copyright Year	2018
Abstract	Up to 95% of the energy in the eukaryotic cells is produced in the mitochondria, which are composed of two membranes, internal and external. The main function of the inner membrane is the oxidative phosphorylation. ATP and/or phosphocreatine produced in mitochondria are transferred to the cytosol across the mitochondrial outer membrane, mainly through the porins (voltage-dependent anion channel, VDAC). As the mechanisms of generation of the electrical potential on this membrane are not known, it is generally assumed that the VDAC electric gate is always open. However, the outer membrane potential (OMP) of mitochondria may be generated by various mechanisms in a manner dependent on the cell energy metabolism. OMP generation by the VDAChexokinase complexes in cancer cells, or by the direct oxidation of cytosolic NADH in the mitochondria of the yeast Saccharomyces cerevisiae, may explain the Crabtree and Warburg effects as an electrical suppression of mitochondria. According to the model developed, the prevention of the formation of the VDAC-hexokinase complexes may result in anti- Warburg and anti-cancer effects. In addition, the generation of the positive OMP by the VDAC-creatine kinase complexes could protect mitochondria in cardiomyocytes and other cells against toxic levels of cytosolic calcium. The mechanisms proposed for OMP generation dependent on the cell energymetabolism suggest that the VDAC electrical properties play an important role in various physiological and pathophysiological processes. © 2018. Acad. Colomb. Cienc. Ex. Fis. Nat.
Starting Page	6
Ending Page	21
Page Count	16
File Format	PDF HTM / HTML
DOI	10.18257/raccefyn.549
Alternate Webpage(s)	https://www.raccefyn.co/index.php/raccefyn/article/download/549/396
Alternate Webpage(s)	https://doi.org/10.18257/raccefyn.549
Volume Number	42
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in