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Fractal kinetics in drug release from finite fractal matrices
| Content Provider | Semantic Scholar |
|---|---|
| Author | Kosmidis, Kosmas Argyrakis, Panos Macheras, Panos |
| Copyright Year | 2003 |
| Abstract | We have re-examined the random release of particles from fractal polymer matrices using Monte Carlo simulations, a problem originally studied by Bunde et al. @J. Chem. Phys. 83, 5909~1985!#. A certain population of particles diffuses on a fractal structure, and as particles reach the boundaries of the structure they are removed from the system. We find that the number of particles that escape from the matrix as a function of time can be approximated by a Weibull ~stretched exponential ! function, similar to the case of release from Euclidean matrices. The earlier result that fractal release rates are described by power laws is correct only at the initial stage of the release, but it has to be modified if one is to describe in one picture the entire process for a finite system. These results pertain to the release of drugs, chemicals, agrochemicals, etc., from delivery systems. © 2003 American Institute of Physics. @DOI: 10.1063/1.1603731 # |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://kelifos.physics.auth.gr/publications/pdf/p110.pdf |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Agrochemicals Approximation algorithm Drug Liberation Fractal Kinetics (discipline) Kinetics Internet Protocol Leucaena pulverulenta Monte Carlo method Particle Polymer Simulation The Matrix exponential |
| Content Type | Text |
| Resource Type | Article |
