Mechanistic state vector model for cell killing by ionizing radiation.

Content Provider	Semantic Scholar
Author	Scott, Bobby R.
Copyright Year	1977
Abstract	By use of the mechanistic state vector model (MSV model) it is demonstrated that under circumstances where cell division during irradiation is unlikely: 1. A cell survival curve (dose-log surviving fraction curve) that is exponential can be obtained even though some of the surviving cells may have nonlethal damage. Exponential survival curves are said to have zero curvature. 2. In some cases, in the absence of a mixed population, the slope of a single-dose survival curve may decrease in magnitude, as the dose increases for a range of doses. These curves are said to show negative curvature for that range of doses. Fractionating the dose or decreasing the dose rate may result in enhanced cell killing. 3. The initial slope of a mammalian cell survival curve should be independent of the dose rate and number of dose fractions provided that the number of cells having lethal damage builds up to a steady level during the post irradiation time regime. The magnitude of the initial slope will depend on properties of the cells and on properties of the radiation. 4. A nonzero initial slope in the cell survival curve, after exposure to low linear energy transfer (LET) radiation, may be due to biology, rather than physics.
Starting Page	195
Ending Page	211
Page Count	17
File Format	PDF HTM / HTML
Alternate Webpage(s)	https://page-one.live.cf.public.springer.com/pdf/preview/10.1007/BF01323939
PubMed reference number	928628v1
Volume Number	14
Issue Number	3
Journal	Radiation and environmental biophysics
Language	English
Access Restriction	Open
Subject Keyword	Arabic numeral 0 Cell Survival Cell division Ionizing radiation Lupus erythematosus tumidus Mammals exponential
Content Type	Text
Resource Type	Article