Effects of SCH-23390 and Raclopride on Cocaine Discrimination in Male and Female Wistar Rats

Content Provider	Semantic Scholar
Author	Anderson, Karen G. Haaren, Frans Van
Copyright Year	2000
Abstract	Male and female rats were trained to discriminate 10.0 mg/kg cocaine from saline in a two-lever discrimination task. Injection-appropriate responding was reinforced by food pellet presentation on a tandem random-interval 30-s fixed-ratio 10 schedule. Generalization testing was conducted in extinction 10 min following an injection of saline, 1.0, 3.0, 5.6, or 10.0 mg/kg cocaine. No differences in the generalization gradients and ED(50)s were observed between male and female rats. Following the determination of the cocaine generalization gradient, the dopamine D(1) antagonist SCH-23390 (0.01-0.10 mg/kg) and the dopamine D(2) antagonist raclopride (0.1-1.6 mg/kg) were administered (independently) prior to the injection of the training dose of cocaine (10.0 mg/kg). Cocaine-antagonism tests were conducted in extinction. It was found, for each dopamine antagonist, that as the dose increased, the percentage of cocaine-appropriate responding decreased. No sex differences were observed between these generalization gradients.
Starting Page	671
Ending Page	675
Page Count	5
File Format	PDF HTM / HTML
DOI	10.1016/S0091-3057(99)00256-7
PubMed reference number	10764921
Journal	Medline
Volume Number	65
Alternate Webpage(s)	https://api.elsevier.com/content/article/pii/S0091305799002567
Alternate Webpage(s)	https://www.sciencedirect.com/science/article/pii/S0091305799002567?dgcid=api_sd_search-api-endpoint
Alternate Webpage(s)	https://doi.org/10.1016/S0091-3057%2899%2900256-7
Journal	Pharmacology Biochemistry and Behavior
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article