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Synthesis and cytotoxicity evaluation of [(2,4-dichlorophenoxy)methyl]-5-aryl-1,3,4-oxadiazole/4$H$-1,2,4-triazole analogues
| Content Provider | Semantic Scholar |
|---|---|
| Author | Ahsan, Mohamed Jawed |
| Copyright Year | 2018 |
| Abstract | We report herein the synthesis, characterization, and cytotoxicity evaluations of some newer oxadiazole and triazole analogues ( 5a-j ). The cytotoxicity of all the title compounds were evaluated as per the National Cancer Institute protocol in a one-dose assay (10 μ " role="presentation"> μ μ \mu M) on nine different panels of 59 cancer cell lines. 2- { " role="presentation"> { { \{ 5-[(2,4-Dichlorophenoxy)methyl]-1,3,4-oxadiazol-2-yl } " role="presentation"> } } \} phenol ( 5e ) showed the maximum cytotoxicity among the series of ten compounds. The cytotoxicity of 5e was comparable to that of the standard anticancer drug, 5-fluorouracil, and better than that of imatinib. The structure activity relationship was also discussed. |
| Starting Page | 1334 |
| Ending Page | 1343 |
| Page Count | 10 |
| File Format | PDF HTM / HTML |
| DOI | 10.3906/kim-1803-25 |
| Volume Number | 42 |
| Alternate Webpage(s) | http://journals.tubitak.gov.tr/chem/issues/kim-18-42-5/kim-42-5-12-1803-25.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
