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Antibacterial Activities of Ramalin, Usnic Acid and its Three Derivatives Isolated from the Antarctic Lichen Ramalina terebrata
| Content Provider | Semantic Scholar |
|---|---|
| Author | Paudel, Babita Bhattarai, Hari Datta Oh, Hyuncheol Shin, Hyun Woung Yim, Joung Han |
| Copyright Year | 2010 |
| Abstract | The development of new antibacterial compounds is an urgent issue to meet the evolution of resistivity of pathogenic bacteria against the available drugs. The objective of this study was to investigate the antibacterial compounds from the Antarctic lichen species Ramalina terebrata. A total of fi ve compounds, usnic acid, usimine A, usimine B, usimine C, and ramalin, were isolated by bioactivity guided-fractionation of the methanol extract of R. terebrata after several chromatographic procedures. The qualitative antibacterial activities of the crude extract and isolated compounds were determined by the disk diffusion method while the minimum inhibitory concentration (MIC) determination assay gave the quantitative strength of the test samples. All the test samples showed antibacterial activity against Bacillus subtilis. The crude extract and usnic acid showed antibacterial activity against Staphylococcus aureus. The MIC values of the isolated compounds against B. subtilis were in the range of 1 to 26 μg/mL. These observed experimental data showed the strong antibacterial potential of these compounds against B. subtilis. |
| Starting Page | 34 |
| Ending Page | 38 |
| Page Count | 5 |
| File Format | PDF HTM / HTML |
| DOI | 10.1515/znc-2010-1-206 |
| Alternate Webpage(s) | http://www.znaturforsch.com/s65c/s65c0034.pdf |
| Alternate Webpage(s) | https://www.degruyter.com/downloadpdf/j/znc.2010.65.issue-1-2/znc-2010-1-206/znc-2010-1-206.pdf |
| Alternate Webpage(s) | http://www.znaturforsch.com/ac/v65c/65c0034.pdf |
| PubMed reference number | 20355318 |
| Alternate Webpage(s) | https://doi.org/10.1515/znc-2010-1-206 |
| Journal | Medline |
| Volume Number | 65 |
| Journal | Zeitschrift fur Naturforschung. C, Journal of biosciences |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
