Loading...
Please wait, while we are loading the content...
Similar Documents
Neuronal hyperexcitability in the dorsal horn after painful facet joint injury
| Content Provider | Semantic Scholar |
|---|---|
| Author | Quinn, Kyle P. Dong, Ling Ling Golder, Francis J. Winkelstein, Beth A. |
| Copyright Year | 2010 |
| Abstract | Excessive cervical facet capsular ligament stretch has been implicated as a cause of whiplash-associated disorders following rear-end impacts, but the pathophysiological mechanisms that produce chronic pain in these cases remain unclear. Using a rat model of C6-C7 cervical facet joint capsule stretch that produces sustained mechanical hyperalgesia, the presence of neuronal hyperexcitability was characterized 7 days after joint loading. Extracellular recordings of spinal dorsal horn neuronal activity between C6 and C8 (117 neurons) were obtained from anesthetized rats, with both painful and non-painful behavioral outcomes established by the magnitude of capsule stretch. The frequency of neuronal firing during noxious pinch (p<0.0182) and von Frey filaments applications (4-26g) to the forepaw was increased (p<0.0156) in the painful group compared to the non-painful and sham groups. In addition, the incidence and frequency of spontaneous and after discharge firing were greater in the painful group (p<0.0307) relative to sham. The proportion of cells in the deep laminae that responded as wide dynamic range neurons also was increased in the painful group relative to non-painful or sham groups (p<0.0348). These findings suggest that excessive facet capsule stretch, while not producing visible tearing, can produce functional plasticity of dorsal horn neuronal activity. The increase in neuronal firing across a range of stimulus magnitudes observed at day 7 post-injury provides the first direct evidence of neuronal modulation in the spinal cord following facet joint loading, and suggests that facet-mediated chronic pain following whiplash injury is driven, at least in part, by central sensitization. |
| Starting Page | 414 |
| Ending Page | 421 |
| Page Count | 8 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/j.pain.2010.07.034 |
| PubMed reference number | 20739124 |
| Journal | Medline |
| Volume Number | 151 |
| Alternate Webpage(s) | http://spinepain.seas.upenn.edu/KPQ_2010.pdf |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/S0304395910004707 |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/S0304395910004707?dgcid=api_sd_search-api-endpoint |
| Journal | PAIN® |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
