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Trypanosoma gambienseの抗原変異について : I.感染家兎に再発する抗原変異型原虫に対する抗体の検出。
| Content Provider | Semantic Scholar |
|---|---|
| Author | Aand, Toshihide F. U. K. U. M. Kanbara, Hiroji Shinka, Sohei Nakabayashi, Toshio |
| Copyright Year | 2018 |
| Abstract | Mode of relapse of Trypanosoma gambiense (Tg) was studied. Antigenic variants were derived from a Tg clone of original antigen type (Tg-O) in 500 ddO mice as the first relapse. Variable antigenic type (VAT) of those variants was determined by agglutination tests with a series of rabbit sera taken from a Tg-O infected rabbit every 2-3 days along the time course of infection. In VAT determination procedure, antibodies in the rabbit sera were traced with those variants derived in mice. Immunologically distinct 27 VATs except Tg-O were isolated and consequently antibodies against them were detected in the rabbit sera. Antibodies against 5 and 2 different VATs were newly detected in the rabbit serum sample collected on day 9 and 11 respectively and antibodies against 4 VATs, on day 14, 16 and 18. In the first relapse in mice two particular VATs were most predominantly expressed and homologous antibodies to them were detected in the rabbit sera in the earliest next to anti-Tg-O antibodies. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://naosite.lb.nagasaki-u.ac.jp/dspace/bitstream/10069/4391/1/tm26_04_03_t.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
