Loading...
Please wait, while we are loading the content...
Similar Documents
Ethanol Extract of Cissus quadrangularis Enhances Osteoblast Differentiation and Mineralization of Murine Pre-Osteoblastic MC3T3-E1 Cells.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Tasadduq, Raazia Gordon, Jonathan A. R. Al-Ghanim, K. A. Lian, Jane B. Wijnen, Andre J. Van Stein, Janet L. Stein, Gary S. Shakoori, Abdul Rauf |
| Copyright Year | 2017 |
| Abstract | Traditional medicinal literature and previous studies have reported the possible role of Cissus quadrangularis (CQ) as an anti-osteoporotic agent. This study examines the effectiveness of CQ in promoting osteoblast differentiation of the murine pre-osteoblast cell line, MC3T3-E1. Ethanolic extract of CQ (CQ-E) was found to affect growth kinetics of MC3T3-E1 cells in a dosage-dependent manner. High concentrations of CQ-E (more than 10 μg/ml) have particularly adverse effects, while lower concentrations of 0.1 and 1 µg/ml were non-toxic and did not affect cell viability. Notably, cell proliferation was significantly increased at the lower concentrations of CQ-E. CQ-E treatment also augmented osteoblast differentiation, as reflected by a substantial increase in expression of the early osteoblast marker ALP activity, and at later stage, by mineralization of extracellular matrix compared to the control group. These findings suggest dose-dependent effect of CQ-E with lower concentrations exhibiting anabolic and osteogenic properties. J. Cell. Physiol. 232: 540-547, 2017. © 2016 Wiley Periodicals, Inc. |
| Starting Page | 540 |
| Ending Page | 547 |
| Page Count | 8 |
| File Format | PDF HTM / HTML |
| DOI | 10.1002/jcp.25449 |
| PubMed reference number | 27264191 |
| Journal | Medline |
| Volume Number | 232 |
| Issue Number | 3 |
| Alternate Webpage(s) | http://fac.ksu.edu.sa/sites/default/files/ethanol_extract_of_cissus_quadrangularis_of_cellular_physiology_onlinelibrarytps.pdf |
| Alternate Webpage(s) | https://doi.org/10.1002/jcp.25449 |
| Journal | Journal of cellular physiology |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
