NDLI: Monodisperse Nanoparticles of Poly ( ethylene glycol ) Macromers and N-Isopropyl Acrylamide for Biomedical Applications

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Monodisperse Nanoparticles of Poly ( ethylene glycol ) Macromers and N-Isopropyl Acrylamide for Biomedical Applications

Content Provider	Semantic Scholar
Author	Leobandung, William Ichikawa, Hideki Fukumori, Yoshinobu Peppas, Nicholas A.
Copyright Year	2002
Abstract	Poly(ethylene glycol)-based nanoparticles have received significant attention in the field of biomedicine. When they are copolymerized with pHor temperature-sensitive comonomers, their small size allows them to respond very quickly to changes in the environment, including changes in the pH, ionic strength, and temperature. In addition, the high surface-to-volume ratio makes them highly functionalized. In this work, nanoparticles composed of temperature-sensitive poly(N-isopropylacrylamide), poly(ethylene glycol) 400 dimethacrylate, and poly(ethylene glycol) 1000 methacrylate were prepared by a thermally initiated, free-radical dispersion polymerization method. The temperature-responsive behavior of the hydrogel nanoparticles was characterized by the study of their particle size with photon correlation spectroscopy. The size of the nanoparticles varied from 200 to 1100 nm and was a strong function of the temperature of the system, from 5 to 40°C. The thermal, structural, and morphological characteristics were also investigated. © 2002 Wiley Periodicals, Inc. J Appl Polym Sci 87: 1678–1684, 2003
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.che.utexas.edu/research/biomat/PDFReprints/JApplPolymerSci_87_1678-1684(2003).pdf
Language	English
Access Restriction	Open
Subject Keyword	Acrylamide Ammonium Argon Artificial nanoparticles Biomedicine Charge (electrical) Dispersed Phase Drug Delivery Systems Enterobacteria phage SCI Exhibits as Topic Galaxy morphological classification Hydrogel Ionic Strength John D. Wiley Maxima and minima Methacrylates Nash equilibrium One Thousand POLYETHYLENE GLYCOL 3350 17000 MG Powder for Oral Solution Particle Size Particulate (substance) Percent Mass per Mass Photon Correlation Spectroscopy Photons Poly A Polyethylene Glycols SCSI initiator and target Tomography, Emission-Computed, Single-Photon Transmission Electron Microscopy ethylene glycol monomer poly(ethylene glycol)-dimethacrylate
Content Type	Text
Resource Type	Article

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