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Novel approaches to the analysis of steroid estrogens in river sediments.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Hájková, Katerina Pulkrabova, Jana Schůrek, Jakub Hajslova, Jana Poustka, Jan Nápravníková, Michaela Kocourek, Vladimír |
| Copyright Year | 2007 |
| Abstract | A wide range of estrogenic contaminants has been detected in the aquatic environment. Among these, natural and synthetic steroid estrogens, typically present in municipal sewage-treatment plant (STP) effluents, are the most potent. In this study a new GC-MS method has been developed for direct analysis of five major steroid estrogens (estrone, 17beta-estradiol, 17alpha-ethinylestradiol, dienestrol, and diethylstilbestrol) in river sediments. Four GC-MS systems used for analysis of underivatized analytes in purified extracts were compared. Relatively low detection limits (1.5-5 ng g(-1) dried sediment) and good repeatability of GC splitless injection (RSD 1-2%) were achieved by use of a system combining low-pressure gas chromatography with a single-quadrupole mass analyzer (LP-GC-MS). Use of orthogonal gas chromatography (GCxGC) hyphenated with high-speed time-of-flight mass spectrometry (HSTOF-MS) enabled not only significantly better resolution of target analytes, and their unequivocal identification, but also further improvement (decrease) of their detection limits. In addition to these outcomes, use of this unique GCxGC-TOF-MS system enabled identification of several other non-target chemicals, including pharmaceutical steroids, present in purified sediment extracts. |
| Starting Page | 2 |
| Ending Page | 6 |
| Page Count | 5 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://web.vscht.cz/~hajslovj/publications/hajkova_estrogens_abc_vol387_p1351-1363.pdf |
| PubMed reference number | 17219098v1 |
| Volume Number | 387 |
| Issue Number | 4 |
| Journal | Analytical and bioanalytical chemistry |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Analyzer Device Component Analyzer, device Cold Temperature Dienestrol Diethylstilbestrol Dosage Forms Estrogens Estrone Ethinyl Estradiol Gas Chromatography Gases Mass Analyzer Phase I/II Trial Quadrupole STP protein, Herpesvirus saimiri Sediment Spectrometry Steroids Tracer Xenobiotics analyte standards characteristics |
| Content Type | Text |
| Resource Type | Article |
