Loading...
Please wait, while we are loading the content...
Similar Documents
Measurement of DNA damage in bladder cancer patients by alkaline comet assay
| Content Provider | Semantic Scholar |
|---|---|
| Author | Islam, Jahidul Kabir, Yearul |
| Copyright Year | 2019 |
| Abstract | Introduction Bladder cancer is the most common cancer of the urinary tract. DNA damage is responsible for genomic instability, which is a hallmark of bladder carcinogenesis. Cigarette smoking induced DNA damage is one of the major risk factors associated with this disease. Methods We used the alkaline comet assay to measure DNA damage in peripheral blood lymphocytes from 38 bladder cancer patients and 26 healthy control subjects. All subjects provided personal information, including smoking history. DNA damage was quantified by calculating the %tail DNA (%TD) and olive tail moment (OTM) parameter. Results It was found that patients (%TD 20.09 ± 1.67 and OTM 31.31 ± 2.82) had significant DNA damage compared with control subjects (%TD 2.70 ± 0.48 and OTM 9.34 ± 1.30). Besides, patients with extensive smoking history had higher DNA damage compared to non- |
| Starting Page | 51 |
| Ending Page | 57 |
| Page Count | 7 |
| File Format | PDF HTM / HTML |
| DOI | 10.32948/auo.2019.12.26 |
| Alternate Webpage(s) | http://auo.asmepress.com/Uploads/file/20200104/20200104132600_55554.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
