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Systemic sclerosis patients with and without pulmonary arterial hypertension: a nailfold capillaroscopy study.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Riccieri, Valeria Vasile, Massimiliano Iannace, Nicoletta Stefanantoni, Katia Sciarra, Iliana Vizza, Carmine Dario Badagliacca, Roberto Poscia, Roberto Papa, Silvia Mezzapesa, Mario Nocioni, Martina Valesini, Guido |
| Copyright Year | 2013 |
| Abstract | OBJECTIVE Pulmonary arterial hypertension (PAH) is a complication of SSc due to increased vascular resistance, and abnormal vascularity is a well-known feature of the disease as shown by nailfold videocapillaroscopy (NVC). This study investigated for specific NVC changes in SSc patients with and without PAH to assess any useful difference. METHODS Twenty-four SSc patients, 12 with PAH and 12 without, entered the study. Evidence of PAH was defined as increased systolic pulmonary artery pressure (PAP) (≥35 mmHg), indirectly assessed by echocardiography and confirmed by right heart catheterization (mPAP > 25 mmHg). NVC was performed, and a semi-quantitative rating scale, a rating system for avascular areas and a specific NVC pattern evaluation, namely early, active and late, were used. RESULTS An NVC score >1 was more frequently found in patients with PAH than those without, 11 cases (92%) vs 5 cases (42%) (P = 0.03); an avascular areas grade >1 was present in 10 (83%) and 2 (17%) cases, respectively (P = 0.003); and a more severe NC pattern (active/late) was described in 11 (92%) and 5 (42%) patients, respectively (P = 0.03). When we compared the mPAP with NVC parameters, we found significant correlations between mPAP values and the NVC score (P < 0.005) and with the avascular areas score (P < 0.001). CONCLUSION Our results underline the relevance of early microvascular assessment in patients at risk of developing a severe complication such as PAH that can amplify the systemic microvascular impairment in SSc. More severe NVC abnormalities should lead to strict cardiopulmonary surveillance and a complete NVC study is indicated. |
| File Format | PDF HTM / HTML |
| DOI | 10.1093/rheumatology/ket168 |
| PubMed reference number | 23671125 |
| Journal | Medline |
| Volume Number | 52 |
| Issue Number | 8 |
| Alternate Webpage(s) | https://oup.silverchair-cdn.com/oup/backfile/Content_public/Journal/rheumatology/52/8/10.1093/rheumatology/ket168/2/ket168.pdf?Expires=1491532974&Key-Pair-Id=APKAIUCZBIA4LVPAVW3Q&Signature=HMCDCdWEGOcfv-ECDNY2lvfl~7V5V1cINGvi95cHuW16kOa~8wI7s78fnkPAaIRPZb8qIFXYqimEHLrlvz5Uc0F7rFUvKVjY45zwlabQr3Unqcbpp52VKwgT24tMfoQTGKw7V4-zh2CFos~ma6cEe-XFDxOuT8mfN8B0SO-f3pJRp1~eVOmOCzUYbU~NMfon4vWaRlbtvL9HD0~pLETeO63uSnyPW~cLUOgV3a~ifMq07hFhcn6Xoh0A7vemThHCkfh78DZRdLOozLTdS5xPf8tJ4vyukW548rpZ61eMELxtEDYvuGaG8nzj2egj9wMlZ57rgZ6T8oy1MqbflRhcKQ__ |
| Alternate Webpage(s) | https://doi.org/10.1093/rheumatology%2Fket168 |
| Journal | Rheumatology |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
