Effects of haloperidol administration on in vivo extracellular dopamine in striatum and prefrontal cortex after partial dopamine lesions

Content Provider	Semantic Scholar
Author	Bean, Andrew J. Roth, Robert H.
Copyright Year	1991
Abstract	The effects of haloperidol on striatal and prefrontal cortical extracellular fluid dopamine (DA) concentrations were examined in sham-operated control rats and in rats which had received partial lesions of their dopamine systems. In control rats haloperidol administration produced increases in extracellular fluid DA concentrations in both the striatum and prefrontal cortex. However, in rats which had been partially lesioned with intracerebroventricular 6-hydroxydopamine, haloperidol produced an increase in extracellular fluid DA concentration in the prefrontal cortex but failed to alter striatal DA release. These data suggest that nigrostriatal and mesocortical DA neurons have different response capabilities following partial DA lesions.
Starting Page	155
Ending Page	158
Page Count	4
File Format	PDF HTM / HTML
DOI	10.1016/0006-8993(91)90613-Z
Alternate Webpage(s)	https://api.elsevier.com/content/article/pii/000689939190613Z
Alternate Webpage(s)	https://www.sciencedirect.com/science/article/pii/000689939190613Z?dgcid=api_sd_search-api-endpoint
PubMed reference number	1909923
Alternate Webpage(s)	https://doi.org/10.1016/0006-8993%2891%2990613-Z
Journal	Medline
Volume Number	549
Journal	Brain Research
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article